The series takes place in the year 2027, where many people in developed countries have become cyborgs with prosthetic bodies. Primarily set in the fictional Japanese Newport City, the series follows a younger Motoko Kusanagi before the formation of Public Security Section 9. At the start of Arise she is a member of the federal 501 Organization, a group who employs advanced infiltration tactics and espionage in order to attack or neutralize enemy threats. The 501 Organization is also the legal owner of Kusanagi’s prosthetic body, which is lent to her in exchange for her services to the group. This debt displeases her and causes a disparity between herself and her employer.